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Characterization of Cimetidine–Piroxicam Coprecipitate Interaction Using Experimental Studies and Molecular Dynamic Simulations

The crystalline states of cimetidine and piroxicam, when coprecipitated from solvents containing 1:1 mole ratio, were transformed to amorphous states as observed using powder X-ray diffraction (PXRD). Amorphous forms of drugs generally exhibit higher water solubility than crystalline forms. It is th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Tantishaiyakul, Vimon, Suknuntha, Krit, Vao-Soongnern, Visit
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902308/
https://ncbi.nlm.nih.gov/pubmed/20512435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9461-5
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