Sustained Liver Targeting and Improved Antiproliferative Effect of Doxorubicin Liposomes Modified with Galactosylated Lipid and PEG-Lipid

In this study, a cleavable PEG-lipid (methoxypolyethyleneglycol 2000-cholesteryl hemisuccinate, PEG(2000)-CHEMS) linked via ester bond and galactosylated lipid ((5-cholesten-3β-yl) 4-oxo-4-[2-(lactobionyl amido) ethylamido] butanoate, CHS-ED-LA) were used to modify doxorubicin (DOX) liposome. DOX wa...

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Detalhes bibliográficos
Main Authors: Wang, Shaoning, Xu, Hui, Xu, Jinghua, Zhang, Ying, Liu, Yingchun, Deng, Yi-hui, Chen, Dawei
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902302/
https://ncbi.nlm.nih.gov/pubmed/20490957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9450-8
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