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Physical Characterization of 1,3-dipropyl-8-cyclopentylxanthine (CPX)
1,3-dipropyl-8-cyclopentylxanthine (CPX) has been shown to stimulate in vitro CFTR activity in ∆F508 cells. Data from a phase I study demonstrated erratic bioavailability and no measurable clinical response to oral CPX. One cause for its poor bioavailability may have been dissolution rate limited ab...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Springer US
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902298/ https://ncbi.nlm.nih.gov/pubmed/20440586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9436-6 |
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