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Interaction between a novel TGFB1 haplotype and CFTR genotype is associated with improved lung function in cystic fibrosis

Cystic fibrosis (CF), the most common lethal single gene disorder in Caucasians, is due to mutations in the CFTR gene. Twin and sibling analysis indicates that modifier genes, rather than allelic variation in CFTR, are responsible for most of the variability in severity of lung disease, the major ca...

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Bibliografski detalji
Glavni autori: Bremer, Lindsay A., Blackman, Scott M., Vanscoy, Lori L., McDougal, Kathryn E., Bowers, Amanda, Naughton, Kathleen M., Cutler, David J., Cutting, Garry R.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902288/
https://ncbi.nlm.nih.gov/pubmed/18424453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn123
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