Genetic Variation at the Proprotein Convertase Subtilisin/Kexin Type 5 Gene Modulates HDL Cholesterol Levels

BACKGROUND: A low level of plasma high-density lipoprotein cholesterol (HDL-C) is a risk factor for cardiovascular disease. HDL particles are modulated by a variety of lipases, including endothelial lipase (EL), a phospholipase present on vascular endothelial cells. The proprotein convertase subtili...

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Main Authors: Iatan, Iulia, Dastani, Zari, Do, Ron, Weissglas-Volkov, Daphna, Ruel, Isabelle, Lee, Jenny C., Huertas-Vazquez, Adriana, Taskinen, Marja-Riitta, Prat, Annik, Seidah, Nabil G., Pajukanta, Päivi, Engert, James C., Genest, Jacques
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901678/
https://ncbi.nlm.nih.gov/pubmed/20031622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.109.877811
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