C3 R102G polymorphism increases risk of age-related macular degeneration

Inflammation has long been suspected to play a role in the pathogenesis of age-related macular degeneration (AMD). Association of variants in the complement factor H (CFH) and complement factor B (CFB) genes has targeted the search for additional loci to the alternative complement cascade, of which...

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Autori principali: Spencer, Kylee L., Olson, Lana M., Anderson, Brent M., Schnetz-Boutaud, Nathalie, Scott, William K., Gallins, Paul, Agarwal, Anita, Postel, Eric A., Pericak-Vance, Margaret A., Haines, Jonathan L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900893/
https://ncbi.nlm.nih.gov/pubmed/18325906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn075
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