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ANTITHROMBOTIC PROPERTIES OF IXOLARIS, A POTENT INHIBITOR OF THE EXTRINSIC PATHWAY OF THE COAGULATION CASCADE
Ixolaris is a two-Kunitz tick salivary gland protein identified in Ixodes scapularis that presents extensive sequence homology to TFPI. It binds to FXa or FX as scaffolds and inhibits extrinsic Xnase. Differently from TFPI, however, Ixolaris does not bind to the active site cleft of FXa. Instead, co...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900789/ https://ncbi.nlm.nih.gov/pubmed/16807644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH06-02-0105 |
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