Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses

One half of a group of 20 patients with human papillomavirus type 16 (HPV16)-induced vulvar intraepithelial neoplasia grade 3 displayed a complete regression (CR) after therapeutic vaccination with HPV16 E6/E7 synthetic long peptides. Patients with relatively larger lesions generally did not display...

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Main Authors: Welters, Marij J. P., Kenter, Gemma G., de Vos van Steenwijk, Peggy J., Löwik, Margriet J. G., Berends-van der Meer, Dorien M. A., Essahsah, Farah, Stynenbosch, Linda F. M., Vloon, Annelies P. G., Ramwadhdoebe, Tamara H., Piersma, Sytse J., van der Hulst, Jeanette M., Valentijn, A. Rob P. M., Fathers, Lorraine M., Drijfhout, Jan W., Franken, Kees L. M. C., Oostendorp, Jaap, Fleuren, Gert Jan, Melief, Cornelis J. M., van der Burg, Sjoerd H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900675/
https://ncbi.nlm.nih.gov/pubmed/20547850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006500107
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