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Altered cortical CDC42 signaling pathways in schizophrenia: Implications for dendritic spine deficits

BACKGROUND: Spine density on the basilar dendrites of pyramidal neurons is lower in layer 3, but not in layers 5-6, in the dorsolateral prefrontal cortex (DLPFC) of subjects with schizophrenia. The expression of CDC42 (cell division cycle 42), a RhoGTPase which regulates the outgrowth of the actin c...

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Detalles Bibliográficos
Autores principales: Ide, Masayuki, Lewis, David A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900524/
https://ncbi.nlm.nih.gov/pubmed/20385374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2010.02.016
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