Mitochondrial dysfunction may explain the cardiomyopathy of chronic iron overload

In patients with hemochromatosis, cardiac dysfunction may appear years after they have reached a state of iron overload. We hypothesized that cumulative iron-catalyzed oxidant damage to mitochondrial DNA (mtDNA) might explain the cardiomyopathy of chronic iron overload. Mice were given repetitive in...

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Hauptverfasser: Gao, Xueshan, Qian, Mingwei, Li Campian, Jian, Marshall, James, Zhou, Zhanxiang, Roberts, Andrew M., Kang, Y. James, Prabhu, Sumanth D., Sun, Xiao-Feng, Eaton, John W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900522/
https://ncbi.nlm.nih.gov/pubmed/20450972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.04.033
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