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Valproic Acid Induces Notch1 Signaling in Small Cell Lung Cancer Cells

BACKGROUND: Small cell lung cancer (SCLC) is an aggressive malignancy. Current treatments yield dismal survival rates. We have previously demonstrated that histone deacetylase (HDAC) inhibitors can inhibit neuroendocrine tumor growth. Activation of the Notch1 signaling pathway also impairs SCLC cell...

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Detalhes bibliográficos
Principais autores: Platta, Christopher S., Greenblatt, David Yü, Kunnimalaiyaan, Muthusamy, Chen, Herbert
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900385/
https://ncbi.nlm.nih.gov/pubmed/18570928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2008.03.008
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