Dynamics of HIV-1 Quasispecies during Antiviral Treatment Dissected Using Ultra-Deep Pyrosequencing

BACKGROUND: Ultra-deep pyrosequencing (UDPS) allows identification of rare HIV-1 variants and minority drug resistance mutations, which are not detectable by standard sequencing. PRINCIPAL FINDINGS: Here, UDPS was used to analyze the dynamics of HIV-1 genetic variation in reverse transcriptase (RT)...

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Bibliografiske detaljer
Main Authors: Hedskog, Charlotte, Mild, Mattias, Jernberg, Johanna, Sherwood, Ellen, Bratt, Göran, Leitner, Thomas, Lundeberg, Joakim, Andersson, Björn, Albert, Jan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898805/
https://ncbi.nlm.nih.gov/pubmed/20628644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011345
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