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Interconversion of the Specificities of Human Lysosomal Enzymes Associated with Fabry and Schindler Diseases
The human lysosomal enzymes α-galactosidase (α-GAL, EC 3.2.1.22) and α-N-acetylgalactosaminidase (α-NAGAL, EC 3.2.1.49) share 46% amino acid sequence identity and have similar folds. The active sites of the two enzymes share 11 of 13 amino acids, differing only where they interact with the 2-positio...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2898384/ https://ncbi.nlm.nih.gov/pubmed/20444686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.118588 |
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