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Common and Uncommon Pathogenic Cascades in Lysosomal Storage Diseases
Lysosomal storage diseases (LSDs), of which about 50 are known, are caused by the defective activity of lysosomal proteins, resulting in accumulation of unmetabolized substrates. As a result, a variety of pathogenic cascades are activated such as altered calcium homeostasis, oxidative stress, inflam...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2898325/ https://ncbi.nlm.nih.gov/pubmed/20430897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R110.134452 |
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