Functional and Genetic Studies of the Substrate Specificity of Coronavirus Infectious Bronchitis Virus 3C-Like Proteinase

Coronavirus (CoV) 3C-like proteinase (3CLpro), located in nonstructural protein 5 (nsp5), processes the replicase polyproteins 1a and 1ab (pp1a and pp1ab) at 11 specific sites to produce 12 mature nonstructural proteins (nsp5 to nsp16). Structural and biochemical studies suggest that a conserved Gln...

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Detalles Bibliográficos
Main Authors: Fang, Shouguo, Shen, Hongyuan, Wang, Jibin, Tay, Felicia P. L., Liu, Ding Xiang
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898227/
https://ncbi.nlm.nih.gov/pubmed/20444893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02490-09
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