Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T Antigens

Merkel cell carcinoma (MCC) is the most aggressive skin cancer. Recently, it was demonstrated that human Merkel cell polyomavirus (MCV) is clonally integrated in ∼80% of MCC tumors. However, direct evidence for whether oncogenic viral proteins are needed for the maintenance of MCC cells is still mis...

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Autors principals: Houben, Roland, Shuda, Masahiro, Weinkam, Rita, Schrama, David, Feng, Huichen, Chang, Yuan, Moore, Patrick S., Becker, Jürgen C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Transformation and Oncogenesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898224/
https://ncbi.nlm.nih.gov/pubmed/20444890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02400-09
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