Interferon Regulatory Factor 3 Attenuates Reovirus Myocarditis and Contributes to Viral Clearance

Apoptosis is a pathological hallmark of encephalitis and myocarditis caused by reovirus in newborn mice. In cell culture models, the antiviral transcription factor interferon regulatory factor 3 (IRF-3) enhances reovirus-induced apoptosis following activation via retinoic acid inducible gene I and i...

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Главные авторы: Holm, Geoffrey H., Pruijssers, Andrea J., Li, Lianna, Danthi, Pranav, Sherry, Barbara, Dermody, Terence S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2010
Предметы:
Pathogenesis and Immunity
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898218/
https://ncbi.nlm.nih.gov/pubmed/20463082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01742-09
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