The Lyme Disease Spirochete Borrelia burgdorferi Utilizes Multiple Ligands, Including RNA, for Interferon Regulatory Factor 3-Dependent Induction of Type I Interferon-Responsive Genes

We recently discovered a critical role for type I interferon (IFN) in the development of murine Lyme arthritis. Borrelia burgdorferi-mediated induction of IFN-responsive genes by bone marrow-derived macrophages (BMDMs) was dependent upon a functional type I IFN receptor but independent of Toll-like...

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Detalhes bibliográficos
Main Authors: Miller, Jennifer C., Maylor-Hagen, Heather, Ma, Ying, Weis, John H., Weis, Janis J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897372/
https://ncbi.nlm.nih.gov/pubmed/20404081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01070-09
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