High-frequency Electrically Stimulated Skeletal Muscle Contractions increase p70(s6k) phosphorylation independent of known IGF-I sensitive signaling pathways

Insulin-like growth factor (IGF-I) is hypothesized to be a critical upstream regulator of mTOR-regulated protein synthesis with muscle contraction. We utilized a mouse model that expresses a skeletal muscle specific dominant-negative IGF-I receptor (MKR) to investigate the role of IGF-1 in signaling...

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Bibliographic Details
Main Authors:	Witkowski, Sarah, Lovering, Richard M., Spangenburg, Espen E.
Format:	Artigo
Language:	Inglês
Published:	2010
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2897008/ https://ncbi.nlm.nih.gov/pubmed/20466004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.05.003
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High-frequency Electrically Stimulated Skeletal Muscle Contractions increase p70(s6k) phosphorylation independent of known IGF-I sensitive signaling pathways

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