Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT(2C )receptor-dependent pathways

BACKGROUND: Agomelatine is a melatonergic receptor agonist and a 5HT(2C )receptor antagonist that has shown antidepressant efficacy. In order to analyze separately the effect of the two receptorial components, rats were chronically treated with agomelatine, melatonin (endogenous melatonergic agonist...

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Main Authors: Tardito, Daniela, Milanese, Marco, Bonifacino, Tiziana, Musazzi, Laura, Grilli, Massimo, Mallei, Alessandra, Mocaer, Elisabeth, Gabriel-Gracia, Cecilia, Racagni, Giorgio, Popoli, Maurizio, Bonanno, Giambattista
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
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Research article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896952/
https://ncbi.nlm.nih.gov/pubmed/20525261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-11-68
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