Twisting of the DNA-binding surface by a β-strand-bearing proline modulates DNA gyrase activity

DNA gyrase is the only topoisomerase capable of introducing (−) supercoils into relaxed DNA. The C-terminal domain of the gyrase A subunit (GyrA-CTD) and the presence of a gyrase-specific ‘GyrA-box’ motif within this domain are essential for this unique (−) supercoiling activity by allowing gyrase t...

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Detalhes bibliográficos
Main Authors: Hsieh, Tung-Ju, Yen, Tien-Jui, Lin, Te-Sheng, Chang, Hsun-Tang, Huang, Shu-Yun, Hsu, Chun-Hua, Farh, Lynn, Chan, Nei-Li
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896533/
https://ncbi.nlm.nih.gov/pubmed/20215433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq153
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