N-Glycans on the link domain of human HARE/Stabilin-2 are needed for hyaluronan binding to purified ecto-domain, but not for cellular endocytosis of hyaluronan

The hyaluronic acid receptor for endocytosis (HARE)/Stabilin-2 is the primary systemic scavenger receptor for 13 ligands including hyaluronan (HA), heparin and chondroitin sulfates. Most ligand-binding sites are within the 190 kDa isoform, which contains ∼25 kDa of N-glycans and is the C-terminal ha...

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Hlavní autoři: Harris, Edward N, Parry, Simon, Sutton-Smith, Mark, Pandey, Madhu S, Panico, Maria, Morris, Howard R, Haslam, Stuart M, Dell, Anne, Weigel, Paul H
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895729/
https://ncbi.nlm.nih.gov/pubmed/20466649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwq057
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