Comparative Analysis of DNA Replication Timing Reveals Conserved Large-Scale Chromosomal Architecture

Recent evidence suggests that the timing of DNA replication is coordinated across megabase-scale domains in metazoan genomes, yet the importance of this aspect of genome organization is unclear. Here we show that replication timing is remarkably conserved between human and mouse, uncovering large re...

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Bibliographic Details
Main Authors: Yaffe, Eitan, Farkash-Amar, Shlomit, Polten, Andreas, Yakhini, Zohar, Tanay, Amos, Simon, Itamar
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895651/
https://ncbi.nlm.nih.gov/pubmed/20617169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001011
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