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Comparative Analysis of DNA Replication Timing Reveals Conserved Large-Scale Chromosomal Architecture

Recent evidence suggests that the timing of DNA replication is coordinated across megabase-scale domains in metazoan genomes, yet the importance of this aspect of genome organization is unclear. Here we show that replication timing is remarkably conserved between human and mouse, uncovering large re...

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Detalhes bibliográficos
Main Authors: Yaffe, Eitan, Farkash-Amar, Shlomit, Polten, Andreas, Yakhini, Zohar, Tanay, Amos, Simon, Itamar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895651/
https://ncbi.nlm.nih.gov/pubmed/20617169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001011
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