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Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor
Allostery plays a key role in the regulation of the activity and function of many biomolecules. And although many ligands act through allostery, no systematic use is made of it in drug design strategies. Here we describe a procedure for identifying the regions of a protein that can be used to contro...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2895076/ https://ncbi.nlm.nih.gov/pubmed/20534570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914611107 |
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