Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders

By impairing both function and survival, the severe reduction in oxygen availability associated with high-altitude environments is likely to act as an agent of natural selection. We used genomic and candidate gene approaches to search for evidence of such genetic selection. First, a genome-wide alle...

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Bibliografski detalji
Glavni autori: Beall, Cynthia M., Cavalleri, Gianpiero L., Deng, Libin, Elston, Robert C., Gao, Yang, Knight, Jo, Li, Chaohua, Li, Jiang Chuan, Liang, Yu, McCormack, Mark, Montgomery, Hugh E., Pan, Hao, Robbins, Peter A., Shianna, Kevin V., Tam, Siu Cheung, Tsering, Ngodrop, Veeramah, Krishna R., Wang, Wei, Wangdui, Puchung, Weale, Michael E., Xu, Yaomin, Xu, Zhe, Yang, Ling, Zaman, M. Justin, Zeng, Changqing, Zhang, Li, Zhang, Xianglong, Zhaxi, Pingcuo, Zheng, Yong Tang
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895075/
https://ncbi.nlm.nih.gov/pubmed/20534544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002443107
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