Melphalan, prednisone, thalidomide and defibrotide in relapsed/refractory multiple myeloma: results of a multicenter phase I/II trial

BACKGROUND: Defibrotide is a novel orally bioavailable polydisperse oligonucleotide with anti-thrombotic and anti-adhesive effects. In SCID/NOD mice, defibrotide showed activity in human myeloma xenografts. This phase I/II study was conducted to identify the most appropriate dose of defibrotide in c...

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Dades bibliogràfiques
Autors principals: Palumbo, Antonio, Larocca, Alessandra, Genuardi, Mariella, Kotwica, Katarzyna, Gay, Francesca, Rossi, Davide, Benevolo, Giulia, Magarotto, Valeria, Cavallo, Federica, Bringhen, Sara, Rus, Cecilia, Masini, Luciano, Iacobelli, Massimo, Gaidano, Gianluca, Mitsiades, Constantine, Anderson, Kenneth, Boccadoro, Mario, Richardson, Paul
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895039/
https://ncbi.nlm.nih.gov/pubmed/20053869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.017913
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