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Expression Levels of a Kinesin-13 Microtubule Depolymerase Modulates the Effectiveness of Anti-Microtubule Agents

BACKGROUND: Chemotheraputic drugs often target the microtubule cytoskeleton as a means to disrupt cancer cell mitosis and proliferation. Anti-microtubule drugs inhibit microtubule dynamics, thereby triggering apoptosis when dividing cells activate the mitotic checkpoint. Microtubule dynamics are reg...

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Bibliografiske detaljer
Main Authors: Schimizzi, Gregory V., Currie, Joshua D., Rogers, Stephen L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894863/
https://ncbi.nlm.nih.gov/pubmed/20614032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011381
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