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Opposing microRNA families regulate self-renewal in mouse embryonic stem cells
When embryonic stem cells (ESCs) differentiate, they must both silence the ESC self-renewal program as well as activate new tissue specific programs. In the absence of DGCR8 (Dgcr8 -/-), a protein required for microRNA (miRNA) biogenesis, mouse ESCs are unable to silence self-renewal. Here, we find...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2894702/ https://ncbi.nlm.nih.gov/pubmed/20054295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08725 |
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