Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles

Glycogen synthase kinase-3 (GSK3) is a critical enzyme in neuronal physiology, however any specific role in presynaptic function is not yet known. We show that GSK3 phosphorylates a key residue on the large GTPase dynamin I (Ser-774) both in vitro and in primary rat neuronal cultures. This is depend...

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Main Authors: Clayton, E.L., Sue, N., Smillie, K.J., O’Leary, T., Bache, N., Cheung, G., Cole, A.R., Wyllie, D.J, Sutherland, C., Robinson, P.J., Cousin, M.A
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894011/
https://ncbi.nlm.nih.gov/pubmed/20526333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2571
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