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A Genome-Scale DNA Repair RNAi Screen Identifies SPG48 as a Novel Gene Associated with Hereditary Spastic Paraplegia

DNA repair is essential to maintain genome integrity, and genes with roles in DNA repair are frequently mutated in a variety of human diseases. Repair via homologous recombination typically restores the original DNA sequence without introducing mutations, and a number of genes that are required for...

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Main Authors: Słabicki, Mikołaj, Theis, Mirko, Krastev, Dragomir B., Samsonov, Sergey, Mundwiller, Emeline, Junqueira, Magno, Paszkowski-Rogacz, Maciej, Teyra, Joan, Heninger, Anne-Kristin, Poser, Ina, Prieur, Fabienne, Truchetto, Jérémy, Confavreux, Christian, Marelli, Cécilia, Durr, Alexandra, Camdessanche, Jean Philippe, Brice, Alexis, Shevchenko, Andrej, Pisabarro, M. Teresa, Stevanin, Giovanni, Buchholz, Frank
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2010
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893954/
https://ncbi.nlm.nih.gov/pubmed/20613862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000408
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