Inhibition of mTORC1 signaling reduces tumor growth but does not prevent cancer progression in a mouse model of thyroid cancer

Selective drugs targeting dysregulated oncogenic pathways are promising cancer therapies. Because the mammalian target of rapamycin complex 1 (mTORC1) pathway is hyperactivated in human follicular thyroid cancer (FTC), we hypothesized that its inhibition could block cancer development and progressio...

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Bibliographic Details
Main Authors: Guigon, Celine J., Fozzatti, Laura, Lu, Changxue, Willingham, Mark C., Cheng, Sheue-yann
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Carcinogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893796/
https://ncbi.nlm.nih.gov/pubmed/20299527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgq059
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