Matrix Metalloproteinase Inhibitor Batimastat Alleviates Pathology and Improves Skeletal Muscle Function in Dystrophin-Deficient mdx Mice

Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, involves severe muscle degeneration, inflammation, fibrosis, and early death in afflicted boys. Matrix metalloproteinases (MMPs) are extracellular proteases that cause tissue degradation in several disease states. In this...

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Detalles Bibliográficos
Main Authors: Kumar, Akhilesh, Bhatnagar, Shephali, Kumar, Ashok
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893668/
https://ncbi.nlm.nih.gov/pubmed/20472898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091176
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