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Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-Dependent Manner

Calcified aortic valve (AV) cusps have increased expression of bone morphogenic proteins (BMPs) and transforming growth factor-β1 (TGF-β1). Elevated stretch loading on the AV is known to increase expression of matrix remodeling enzymes and pro-inflammatory proteins. Little, however, is known about t...

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Main Authors: Balachandran, Kartik, Sucosky, Philippe, Jo, Hanjoong, Yoganathan, Ajit P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Investigative Pathology 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893650/
https://ncbi.nlm.nih.gov/pubmed/20489151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090631
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