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TDP-l-Megosamine Biosynthesis Pathway Elucidation and Megalomicin A Production in Escherichia coli

In vivo reconstitution of the TDP-l-megosamine pathway from the megalomicin gene cluster of Micromonospora megalomicea was accomplished by the heterologous expression of its biosynthetic genes in Escherichia coli. Mass spectrometric analysis of the TDP-sugar intermediates produced from operons conta...

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Detalhes bibliográficos
Main Authors: Useglio, Mariana, Peirú, Salvador, Rodríguez, Eduardo, Labadie, Guillermo R., Carney, John R., Gramajo, Hugo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893496/
https://ncbi.nlm.nih.gov/pubmed/20418422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03083-09
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