Environmental Exposure of the Mouse Germ Line: DNA Adducts in Spermatozoa and Formation of De Novo Mutations during Spermatogenesis

BACKGROUND: Spermatozoal DNA damage is associated with poor sperm quality, disturbed embryonic development and early embryonic loss, and some genetic diseases originate from paternal de novo mutations. We previously reported poor repair of bulky DNA-lesions in rodent testicular cells. METHODOLOGY/PR...

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Main Authors: Olsen, Ann-Karin, Andreassen, Åshild, Singh, Rajinder, Wiger, Richard, Duale, Nur, Farmer, Peter B., Brunborg, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893163/
https://ncbi.nlm.nih.gov/pubmed/20596530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011349
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