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Acid-Catalyzed Oxygen-18 Labeling of Peptides for Proteomics Applications
In enzymatic (18)O-labeling strategies for quantitative proteomics, the exchange of carboxyl oxygens at low pH is a common, undesired side reaction. We asked if acid-catalyzed back exchange could interfere with quantitation and whether the reaction itself could be used as an alternative method for i...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892872/ https://ncbi.nlm.nih.gov/pubmed/19243188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac802484d |
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