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Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury
In this study we examined the role of the antioxidant glutathione (GSH) in pulmonary susceptibility to ozone toxicity, utilizing GSH deficient C57BL/6J mice that lack the expression of glutamate-cysteine ligase modifier subunit (GCLM). Gclm(−/−) knockout mice had 70% GSH depletion in the lung. Gclm(...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892220/ https://ncbi.nlm.nih.gov/pubmed/20417186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.04.105 |
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