Progressive Age-Related Impairment of the Late Long-Term Potentiation in Alzheimer’s Disease Presenilin-1 Mutant Knock-in Mice

Presenilin 1 (PS1) mutations are responsible for many early-onset familial Alzheimer’s disease (FAD) cases. While increasing evidence points to impaired synaptic plasticity as an early event in AD, PS1 mutant mice exhibit a paradoxical increase in hippocampal long-term potentiation (LTP). Among PS1...

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Huvudupphovsmän: Auffret, Alexandra, Gautheron, Vanessa, Mattson, Mark P., Mariani, Jean, Rovira, Catherine
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891870/
https://ncbi.nlm.nih.gov/pubmed/20157256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-1302
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