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Progressive Age-Related Impairment of the Late Long-Term Potentiation in Alzheimer’s Disease Presenilin-1 Mutant Knock-in Mice
Presenilin 1 (PS1) mutations are responsible for many early-onset familial Alzheimer’s disease (FAD) cases. While increasing evidence points to impaired synaptic plasticity as an early event in AD, PS1 mutant mice exhibit a paradoxical increase in hippocampal long-term potentiation (LTP). Among PS1...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2891870/ https://ncbi.nlm.nih.gov/pubmed/20157256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-1302 |
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