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Elevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortex

Transgenic (TG) female mice expressing bLHβ-CTP (a chimeric protein derived from the β-subunit of bovine luteinizing hormone [LH] and a fragment of the β-subunit of human chorionic gonadotropin [hCG]) exhibit elevated serum LH, infertility, polycystic ovaries, and ovarian tumors. In humans, increase...

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Autori principali: Kero, Jukka, Poutanen, Matti, Zhang, Fu-Ping, Rahman, Nafis, McNicol, Anne Marie, Nilson, John H., Keri, Ruth A., Huhtaniemi, Ilpo T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC289173/
https://ncbi.nlm.nih.gov/pubmed/10712435
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