Fatal myeloproliferation, induced in mice by TEL/PDGFβR expression, depends on PDGFβR tyrosines 579/581

The t(5;12)(q33;p13) translocation associated with chronic myelomonocytic leukemia (CMML) generates a TEL/PDGFβR fusion gene. Here, we used a murine bone marrow transplant (BMT) assay to test the transforming properties of TEL/PDGFβR in vivo. TEL/PDGFβR, introduced into whole bone marrow by retrovir...

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Publicat a:J Clin Invest
Autors principals: Tomasson, Michael H., Sternberg, David W., Williams, Ifor R., Carroll, Martin, Cain, Danielle, Aster, Jon C., Ilaria, Robert L., Etten, Richard A. Van, Gilliland, D. Gary
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2000
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC289168/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10683371/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8902
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