Fatal myeloproliferation, induced in mice by TEL/PDGFβR expression, depends on PDGFβR tyrosines 579/581

The t(5;12)(q33;p13) translocation associated with chronic myelomonocytic leukemia (CMML) generates a TEL/PDGFβR fusion gene. Here, we used a murine bone marrow transplant (BMT) assay to test the transforming properties of TEL/PDGFβR in vivo. TEL/PDGFβR, introduced into whole bone marrow by retrovir...

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Detalhes bibliográficos
Main Authors: Tomasson, Michael H., Sternberg, David W., Williams, Ifor R., Carroll, Martin, Cain, Danielle, Aster, Jon C., Ilaria, Robert L., Etten, Richard A. Van, Gilliland, D. Gary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2000
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC289168/
https://ncbi.nlm.nih.gov/pubmed/10683371
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