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Toward Homogeneous Erythropoietin: Fine Tuning of the C-Terminal Acyl Donor in the Chemical Synthesis of the Cys(29) –Gly(77) Glycopeptide Domain

Described herein is the chemical synthesis of the Cys(29)-Gly(77) glycopeptide domain (22) of erythropoietin. Our initial ligation strategy targeted a C→N termini condensation between glycopeptide 3 and peptide 4. However, the reaction was hindered by the “unattainable” reactivity, mismatched polari...

詳細記述

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書誌詳細
主要な著者: Yuan, Yu, Chen, Jin, Wan, Qian, Tan, Zhongping, Chen, Gong, Kan, Cindy, Danishefsky, Samuel J.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891568/
https://ncbi.nlm.nih.gov/pubmed/20560636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja808705v
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