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Toward Homogeneous Erythropoietin: Fine Tuning of the C-Terminal Acyl Donor in the Chemical Synthesis of the Cys(29) –Gly(77) Glycopeptide Domain
Described herein is the chemical synthesis of the Cys(29)-Gly(77) glycopeptide domain (22) of erythropoietin. Our initial ligation strategy targeted a C→N termini condensation between glycopeptide 3 and peptide 4. However, the reaction was hindered by the “unattainable” reactivity, mismatched polari...
Gorde:
| Egile Nagusiak: | , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2891568/ https://ncbi.nlm.nih.gov/pubmed/20560636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja808705v |
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