The precore gene of the woodchuck hepatitis virus genome is not essential for viral replication in the natural host.

A number of naturally occurring hepatitis B virus mutants that cannot synthesize the virus precore protein have been identified. Such mutants have been associated with more severe forms of hepatitis, including fulminant hepatitis. The most common mutation observed is a substitution of G to A in the...

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Autors principals: Chen, H S, Kew, M C, Hornbuckle, W E, Tennant, B C, Cote, P J, Gerin, J L, Purcell, R H, Miller, R H
Format: Artigo
Idioma:Inglês
Publicat: 1992
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC289138/
https://ncbi.nlm.nih.gov/pubmed/1501300
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