The precore gene of the woodchuck hepatitis virus genome is not essential for viral replication in the natural host.

A number of naturally occurring hepatitis B virus mutants that cannot synthesize the virus precore protein have been identified. Such mutants have been associated with more severe forms of hepatitis, including fulminant hepatitis. The most common mutation observed is a substitution of G to A in the...

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Hlavní autoři: Chen, H S, Kew, M C, Hornbuckle, W E, Tennant, B C, Cote, P J, Gerin, J L, Purcell, R H, Miller, R H
Médium: Artigo
Jazyk:Inglês
Vydáno: 1992
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC289138/
https://ncbi.nlm.nih.gov/pubmed/1501300
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