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B-cells require “nurturing” by CD4 T cells during development in order to respond in chronic Graft-Versus-Host model of systemic lupus erythematosus
The murine chronic GVH (cGVH) model of SLE is induced by allo-recognition of foreign major histocompatibility complex (MHC) Class II determinants. Previous studies have shown that syngeneic CD4(+) T cells are needed during B cell development in order to induce cGVH response in CD4KO mice. Our presen...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2891082/ https://ncbi.nlm.nih.gov/pubmed/20381429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2010.03.003 |
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