Human immunodeficiency virus type 1 tropism for brain microglial cells is determined by a region of the env glycoprotein that also controls macrophage tropism.

Human immunodeficiency virus type 1 (HIV-1), the agent of AIDS, frequently infects the central nervous system. We inoculated adult human brain cultures with chimeric viruses containing parts of the env gene of a cloned primary isolate from brain tissue, HIV-1 JRFl, inserted into the cloned DNA of a...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	Sharpless, N E, O'Brien, W A, Verdin, E, Kufta, C V, Chen, I S, Dubois-Dalcq, M
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1992
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC289063/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1548785/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.4.2588-2593.1992
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