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MSH6 and PMS2 mutation positive Australian Lynch syndrome families: novel mutations, cancer risk and age of diagnosis of colorectal cancer

BACKGROUND: Approximately 10% of Lynch syndrome families have a mutation in MSH6 and fewer families have a mutation in PMS2. It is assumed that the cancer incidence is the same in families with mutations in MSH6 as in families with mutations in MLH1/MSH2 but that the disease tends to occur later in...

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Main Authors: Talseth-Palmer, Bente A, McPhillips, Mary, Groombridge, Claire, Spigelman, Allan, Scott, Rodney J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890527/
https://ncbi.nlm.nih.gov/pubmed/20487569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1897-4287-8-5
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