Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish

BACKGROUND: In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway. Whether or not this dependence on the primary cilium is a universal feature of vertebrate Hedgehog signalling has remained contentious due, in part,...

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Main Authors: Kim, Hyejeong Rosemary, Richardson, Joanna, van Eeden, Freek, Ingham, Philip W
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Research article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890509/
https://ncbi.nlm.nih.gov/pubmed/20487519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-8-65
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