Peptide antagonism as a mechanism for NK cell activation

Inhibition of natural killer (NK) cells is mediated by MHC class I receptors including the killer cell Ig-like receptor (KIR). We demonstrate that HLA-C binding peptides can function as altered peptide ligands for KIR and antagonize the inhibition mediated by KIR2DL2/KIR2DL3. Antagonistic peptides p...

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Detalles Bibliográficos
Main Authors: Fadda, Lena, Borhis, Gwenoline, Ahmed, Parvin, Cheent, Kuldeep, Pageon, Sophie V., Cazaly, Angelica, Stathopoulos, Stavros, Middleton, Derek, Mulder, Arend, Claas, Frans H. J., Elliott, Tim, Davis, Daniel M., Purbhoo, Marco A., Khakoo, Salim I.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890497/
https://ncbi.nlm.nih.gov/pubmed/20439706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913745107
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