The 11-β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy

OBJECTIVE: 11-β-hydroxysteroid dehydrogenase type 1 (11βHSD1) converts inactive cortisone into active cortisol, thereby amplifying intracellular glucocorticoid action. The efficacy and safety of the 11βHSD1 inhibitor INCB13739 were assessed when added to ongoing metformin monotherapy in patients wit...

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Autori principali: Rosenstock, Julio, Banarer, Salomon, Fonseca, Vivian A., Inzucchi, Silvio E., Sun, William, Yao, Wenqing, Hollis, Gregory, Flores, Robert, Levy, Richard, Williams, William V., Seckl, Jonathan R., Huber, Reid
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2010
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890352/
https://ncbi.nlm.nih.gov/pubmed/20413513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc09-2315
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