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The Role of Lys-12 in Catalysis by Triosephosphate Isomerase: A Two-Part Substrate Approach
We report that the K12G mutation at triosephosphate isomerase (TIM) from Saccharomyces cerevisiae results in: (1) A ca. 50-fold increase in K(m) for the substrate glyceraldehyde 3-phosphate (GAP) and a 60-fold increase in K(i) for competitive inhibition by the intermediate analog 2-phosphoglycolate,...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2890037/ https://ncbi.nlm.nih.gov/pubmed/20481463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100538b |
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